In December 2025, Semmelweis University hosted a landmark international symposium that brought together leading experts in obstetrics, radiology, and pathology to discuss the latest advances in fetal post‑mortem diagnostics. The event, titled “Fetal Imaging: The Non‑Invasive Autopsy and New Horizons,” highlighted the growing shift from traditional autopsies toward minimally invasive, imaging‑driven approaches that respect families while delivering precise diagnostic information.
Semmelweis University’s Role in Advancing Fetal Diagnostics
Semmelweis University, located in Budapest, Hungary, has long been a center for medical innovation. The symposium showcased the university’s multidisciplinary collaboration between the Departments of Obstetrics and Gynecology, Pathology and Experimental Cancer Research, and the Medical Imaging Center (OKK). By combining clinical expertise with cutting‑edge imaging technology, the university positioned itself as a global leader in fetal post‑mortem diagnostics.
Multidisciplinary Collaboration
The event featured presentations from international partners such as Great Ormond Street Hospital in London and the Karolinska Institute. This collaboration underscored the importance of a team approach—radiologists, pathologists, and fetal medicine specialists working together to interpret imaging data and guide targeted tissue sampling.
Key Presentations and Findings
- Dr. Owen Arthurs demonstrated how CT, micro‑CT, and MRI can be integrated into routine pathology workflows, providing rapid, high‑resolution images that capture tissue‑level detail.
- Dr. Ciaran Hutchinson highlighted the role of deep phenotyping, using thousands of cases to refine diagnostic criteria for congenital anomalies.
- Dr. Béla Molnár introduced the latest micro‑CT scanner from his startup 3DHISTECH, illustrating its potential to replace invasive sampling in many cases.
- Case studies presented by Dr. Attila Fintha and Dr. Noémi Jákob showcased photon‑counting CT and post‑mortem ultrasound in real‑time diagnostic scenarios.
Non‑Invasive Autopsy Techniques Covered
CT and Micro‑CT Imaging
Computed tomography (CT) offers rapid acquisition of volumetric data, while micro‑CT provides micron‑level resolution. Together, they enable clinicians to visualize organ systems, detect structural anomalies, and plan targeted biopsies without the need for full dissection.
MRI and Post‑Mortem Ultrasound
Magnetic resonance imaging (MRI) excels in soft‑tissue contrast, making it ideal for evaluating the central nervous system. Post‑mortem ultrasound, meanwhile, offers a low‑cost, bedside option for preliminary assessment, especially in resource‑limited settings.
Targeted Tissue Sampling
By combining imaging data with minimally invasive needle biopsies, pathologists can obtain high‑quality samples from specific regions of interest. This approach reduces tissue loss, preserves morphology, and shortens the overall diagnostic timeline.
Clinical Impact and Future Directions
Improved Diagnostic Accuracy
Imaging‑guided autopsies have demonstrated higher detection rates for congenital heart disease, neural tube defects, and chromosomal abnormalities compared to conventional methods. The ability to correlate imaging findings with histopathology enhances confidence in diagnoses.
Ethical and Practical Benefits
Non‑invasive techniques respect cultural and religious sensitivities, often increasing family acceptance of post‑mortem examinations. Additionally, they reduce the time and cost associated with traditional autopsies, making comprehensive diagnostics more accessible.
Integration into Clinical Practice
Hospitals worldwide are beginning to adopt imaging‑driven protocols. Key steps include establishing multidisciplinary teams, investing in compatible imaging equipment, and developing standardized reporting templates that integrate imaging and histopathology findings.
How Clinicians Can Adopt These Techniques
Training and Resources
Semmelweis University offers workshops and online modules that cover image acquisition, interpretation, and biopsy techniques. Clinicians can also access peer‑reviewed case studies and guidelines published by the Royal College of Pathologists.
Equipment and Partnerships
Partnering with imaging vendors such as 3DHISTECH or established hospital imaging departments can streamline equipment procurement. Many vendors provide training packages and maintenance contracts tailored to fetal imaging workflows.
Case Study: Implementing Micro‑CT at a Regional Hospital
In a recent pilot program, a regional hospital in Hungary integrated a micro‑CT scanner into its perinatal pathology unit. Within six months, the hospital reported a 30% reduction in diagnostic turnaround time and a 25% increase in the detection of subtle skeletal anomalies. The success hinged on close collaboration with Semmelweis University’s imaging specialists and a structured training curriculum.
Take Action: Next Steps for Your Practice
Adopting non‑invasive fetal post‑mortem diagnostics can transform patient care, improve diagnostic accuracy, and align with evolving ethical standards. To begin, consider the following steps:
- Explore how Semmelweis University’s innovations can enhance your diagnostic workflow.
- Schedule a free consultation to discuss integrating non‑invasive autopsy techniques into your department.
- Submit your application today to join a network of leading fetal medicine specialists.
- Share your experiences and questions in the comments below to foster community learning.
By embracing these advanced imaging modalities, clinicians can provide families with clearer answers, reduce procedural burden, and stay at the forefront of fetal medicine. The future of post‑mortem diagnostics is already here—now it’s time to make it a part of your practice.
